Number of articles included (%)
|
30 (67)
|
15 (33)
|
45 (100)
|
Number of studies includeda(%)
|
30 (65)
|
16 (35)
|
46 (100)
|
Prospective
|
25 (54)
|
16 (35)
|
41 (89)
|
Retrospective
|
4 (9)
|
1 (2)
|
5 (11)
|
Number of prevalence datab (%)
|
33 (59)
|
23 (41)
|
56 (100)
|
Total number of participants
|
540,901
|
545,075
|
1085,976
|
Mean N. of participants
|
18,030 ± 38,094
|
34,067 ± 61,325
|
23,608 ± 48,092
|
Total number of known sexc
|
120,765
|
10,077
|
130,842
|
Male
|
58,752
|
3318
|
62,070
|
Female
|
62,013
|
6759
|
68,772
|
M:F ratio
|
48:52
|
25:75
|
45:55
|
Mean age of participantsd
|
41.1 ± 11.3
|
38.0 ± 6.5
|
40.0 ± 9.9
|
Male
|
41.1 ± 11.3
|
38.0 ± 6.8
|
39.9 ± 10.0
|
Female
|
41.2 ± 11.4
|
38.1 ± 6.1
|
40.0 ± 9.8
|
N. of (studies)/prevalence data by subgroup (N. of participants)
|
Publication year
|
1990–2000
|
8
|
(177,201)
|
15
|
(318,391)
|
(18)/23
|
(495,592)
|
2001–2010
|
19
|
(86,512)
|
4
|
(9895)
|
(20)/23
|
(96,407)
|
2011–2018
|
6
|
(277,188)
|
4
|
(216,789)
|
(8)/10
|
(493,977)
|
Population group
|
General population (≥ 18 years)
|
24
|
(489,961)
|
20
|
(466,565)
|
(34)/44
|
(956,526)
|
Children/adolescents (< 18 years)
|
6
|
(43,671)
|
1
|
(73,636)
|
(7)/7
|
(117,307)
|
Specific populatione
|
3
|
(7269)
|
2
|
(4874)
|
(5)/5
|
(12,143)
|
Case definition (8 case definitions)
|
23
|
(339,192)
|
11
|
(298,739)
|
34
|
(637,931)
|
CDC-1994 [22]
|
4
|
(20,037)
|
4
|
(27,454)
|
8
|
(47,491)
|
Holmes [23]
|
2
|
(116,520)
|
2
|
(2980)
|
4
|
(119,500)
|
Australian [25]
|
2
|
(3215)
|
2
|
(2980)
|
4
|
(6195)
|
Oxford [24]
|
1
|
(10,396)
|
3
|
(505,299)
|
4
|
(515,695)
|
CCC [27] ECD [26] PVES [28] NICE [29] f N/Ag
|
1
|
(59,101)
|
1
|
(1874)
|
2
|
(60,975)
|
Country (13 countries)
| | |
Western
|
27
|
(516,617)
|
17
|
(473,009)
|
(34)/44
|
(989,626)
|
Asian
|
5
|
(23,197)
|
5
|
(70,192)
|
(10)/10
|
(93,389)
|
Othersh
|
1
|
(1087)
|
1
|
(1874)
|
(2)/2
|
(2961)
|
Diagnostic method
| | |
Interview (medical test −)
|
19
|
(111,943)
|
3
|
(68,848)
|
(19)/22
|
(180,791)
|
Interview (medical test +)
|
9
|
(57,339)
|
14
|
(17,445)
|
(18)/23
|
(74,784)
|
Physician diagnosis
|
1
|
(114,000)
|
5
|
(435,782)
|
(4)/6
|
(549,782)
|
Medical records
|
4
|
(257,619)
|
1
|
(23,000)
|
(5)/5
|
(280,619)
|