Fig. 5

Correlation between immune/inflammation cells infiltration and glycolysis activity. a A heatmap showed the immune cell types enrichment scores of all samples. Groups based on glycolysis activity and molecular subtypes were shown for each sample (above the heatmap). Note that ** represented the cell types which showed significantly different enrichment between high and low glycolysis groups. b Correlation between PGK1 expression and individual immune cell enrichment scores were analyzed. The Spearman correlation coefficient between PGK1 expression and Th1 cells, Th2 cells, Monocytes, Macrophages, Macrophages M1, Pro B-cells, NKT cells were remarkable. c The scatter plot demonstrated that the Spearman correlation coefficient between PGK1 expression and TIL percentage. d TIL density in different subtypes of breast cancer was shown in the boxplot