Table 2 Univariate and multivariate survival analysis
Univariate analysis | Multivariable analysis (adjusted for age and sex) | |||||
|---|---|---|---|---|---|---|
HR | P > |Z| | 95% CI | HR | P > |Z| | 95% CI | |
AFP (ng/mL) | ||||||
<50 vs. ≥ 50 | 1.613 | 0.088 | 0.932–2.792 | – | – | – |
Tumor size | ||||||
< 5 cm vs. ≥ 5 cm | 1.711 | 0.056 | 0.987–2.968 | – | – | – |
Differentiation | ||||||
Poor vs. others | 1.011 | 0.974 | 0.530–1.928 | – | – | – |
Liver cirrhosis | ||||||
With vs. without | 0.998 | 0.994 | 0.532–1.869 | – | – | – |
Portal vein invasion | ||||||
With vs. without | 4.063 | 0.001 | 1.768–9.339 | 2.393 | 0.091 | 0.869–6.590 |
Lymph node metastasis | ||||||
With vs. without | 3.438 | < 0.001 | 1.933–6.117 | 1.677 | 0.347 | 0.571–4.922 |
HBsAg | ||||||
With vs. without | 0.856 | 0.949 | 0.539–1.672 | – | – | – |
TNM | ||||||
I and II vs. III and IV | 3.056 | < 0.001 | 1.756–5.321 | 1.474 | 0.407 | 0.589–3.690 |
Multifocal | ||||||
Yes vs. without | 2.815 | 0.001 | 1.542–5.140 | 1.235 | 0.640 | 0.510–2.989 |
sCLU expression | ||||||
Positive vs. negative | 2.030 | 0.054 | 0.987–4.175 | – | – | – |
β-catenin expression | ||||||
Positive vs. negative | 1.700 | 0.060 | 0.979–2.953 | – | – | – |
sCLU/β-catenin co-expression | ||||||
Positive vs. negative | 2.155 | 0.007 | 1.237–3.752 | 1.965 | 0.035 | 1.050–3.678 |