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Table 3 Univariable and multivariable Cox regression analysis in the TMA cohort (n = 140)

From: YAP1 is an independent prognostic marker in pancreatic cancer and associated with extracellular matrix remodeling

Variable

OS

DFS

Univariable HR (95% CI)

p

Multivariate HR (95% CI)

p

Univariable HR (95% CI)

p

Multivariable HR (95% CI)

p

Age (> 65)

0.994 (0.658–1.501)

0.977

  

0.760 (0.506–1.144)

0.189

  

Female gender

0.825 (0.557–1.221)

0.336

  

0.675 (0.453–1.005)

0.053

  

BMI (> 25 kg/m2)

1.250 (0.832–1.876)

0.283

  

1.372 (0.913–2.061)

0.128

  

Smoking history

1.510 (1.019–2.239)

0.04*

1.319 (0.868–2.003)

0.195

1.268 (0.852–1.887)

0.242

  

Diabetes

0.782 (0.479–1.277)

0.326

  

0.927 (0.567–1.515)

0.762

  

Symptoms at diagnosis

0.363 (0.132–1.000)

0.05*

0.548 (0.193–1.559)

0.260

0.620 (0.227–1.693)

0.351

  

Tumor location (head)

0.658 (0.390–1.112)

0.118

  

1.143 (0.625–2.092)

0.664

  

Tumor size (> 2 cm)

1.090 (0.653–1.819)

0.741

  

1.215 (0.710–2.079)

0.478

  

T-stage (≥ T2)

1.152 (0.672–1.973)

0.607

  

1.429 (0.795–2.571)

0.233

  

N-stage (≥ N1)

1.474 (0.924–2.352)

0.104

  

1.316 (0.829–2.088)

0.244

  

AJCC-stage (≥ II)

1.426 (0.855–2.379)

0.174

  

1.345 (0.814–2.222)

0.248

  

Histological grade (≥ 3)

1.580 (1.045–2.390)

0.03*

1.728 (1.123–2.657)

0.013*

1.592 (1.050–2.413)

0.028*

1.628 (1.072–2.472)

0.022*

Resection margin (≥ R1)

1.388 (0.926–2.080)

0.112

  

1.585 (1.050–2.394)

0.028*

1.716 (1.127–2.613)

0.012*

Adjuvant chemotherapy

0.712 (0.435–1.166)

0.177

  

1.632 (0.887–3.002)

0.115

  

YAP1 protein expression (High)

1.917 (1.288–2.854)

0.001*

1.870 (1.224–2.855)

0.004*

1.752 (1.178–2.608)

0.006*

1.950 (1.299–2.927)

0.001*

  1. Variables with p ≤ 0.05 were marked with asterisk (*), variables with p ≤ 0.05 in univariable analysis were included in multivariable analysis
  2. AJCC American Joint Committee on Cancer, BMI body mass index, CI confidence interval, DFS disease free survival, HR hazard ratio, N-stage nodal stage, OS overall survival, T-stage tumor stage
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Journal of Translational Medicine

ISSN: 1479-5876

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