Alternatively activated macrophages; a double-edged sword in allergic asthma

Table 2 M2a cell markers in human and mice

Category	M2a markers	Host expression in response to IL-4		References
Category	M2a markers	Human	Mice	References
C-type lectin receptors	MRC1 (CD206)	✓	✓	[20, 23, 24]
C-type lectin receptors	MGL (CD301)	✓	✓	[6, 7, 26, 29, 30]
Enzymes	Arg1		✓	[34,35,36]
Enzymes	TG-2	✓	✓	[23, 43]
Secreted proteins	FIZZ1 (RENTLA)		✓	[23, 50]
Secreted proteins	Ym1 (CHI3L3)		✓	[23, 36]
Chemokine ligands	CCL17, CCL22	✓	✓	[4, 5, 63]
Cytokines	IL-10	✓	✓	[4, 7, 8, 29]
	TGF-β1	✓	✓	[4, 5, 8]
	IL-1RA	✓	✓	[5, 102,103,104]
Signal transduction proteins and transcription factors	STAT6, KLF4, SOCS1, and IRF4	✓	✓	[23, 126, 130, 134]

M2a markers; that are mentioned in this review; are divided into six major categories according to their nature. The host expression of human and mice is included

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