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Table 8 Predictive values for soluble CD44, CD44v6, CD44v8-10 and EpCAM for predicting CCA recurrence using the optimal cut-off derived from the ROC curve in early stage of CCA patients

From: Overexpression of a panel of cancer stem cell markers enhances the predictive capability of the progression and recurrence in the early stage cholangiocarcinoma

Variables

AUC (95% CI)

Cut-off

Sensitivity (%)

Specificity (%)

PPV (%)

NPV (%)

p

CD44

0.670 (0.521–0.819)

0.505

68.0

63.0

51.7

77.4

0.029

CD44v6

0.670 (0.529–0.811)

0.814

68.0

68.0

55.6

78.8

0.029

CD44v8-10

0.702 (0.563–0.841)

0.713

73.0

71.0

59.3

81.8

0.010

EpCAM

0.739 (0.598–0.880)

0.506

68.0

76.0

62.5

80.6

0.002

  1. CD44 cluster of differentiation 44, CD44v CD44 variant, EpCAM epithelial cell adhesion molecules, AUC area under curve, 95% CI 95% confidence interval, PPV positive predictive value, NPV negative predictive value
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Journal of Translational Medicine

ISSN: 1479-5876

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