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Table 8 Predictive values for soluble CD44, CD44v6, CD44v8-10 and EpCAM for predicting CCA recurrence using the optimal cut-off derived from the ROC curve in early stage of CCA patients

From: Overexpression of a panel of cancer stem cell markers enhances the predictive capability of the progression and recurrence in the early stage cholangiocarcinoma

VariablesAUC (95% CI)Cut-offSensitivity (%)Specificity (%)PPV (%)NPV (%)p
CD440.670 (0.521–0.819)0.50568.063.051.777.40.029
CD44v60.670 (0.529–0.811)0.81468.068.055.678.80.029
CD44v8-100.702 (0.563–0.841)0.71373.071.059.381.80.010
EpCAM0.739 (0.598–0.880)0.50668.076.062.580.60.002
  1. CD44 cluster of differentiation 44, CD44v CD44 variant, EpCAM epithelial cell adhesion molecules, AUC area under curve, 95% CI 95% confidence interval, PPV positive predictive value, NPV negative predictive value