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Table 4 Multivariate analysis of factors predicting overall survival

From: Overexpression of a panel of cancer stem cell markers enhances the predictive capability of the progression and recurrence in the early stage cholangiocarcinoma

VariableOverall survival
HR95% CIp
Model A
 Age less (61 or greater vs than 61)1.4291.051–1.9440.023
 Primary tumor (T) (III/IV vs I/II)2.3701.517–3.702< 0.001
 Lymph nodes metastasis (N) (Yes Vs No)1.7531.129–2.7230.012
 TNM stage (III/IV vs I/II)1.0130.576–1.7820.964
 CD44 (high vs low)1.7011.221–2.3710.002
Model B
 Age less (61 or greater vs than 61)1.5101.113–2.0500.008
 Primary tumor (T) (III/IV vs I/II)2.3211.474–3.654< 0.001
 Lymph nodes metastasis (N) (Yes vs No)1.7061.086–2.6820.021
 TNM stage (III/IV vs I/II)0.9870.554–1.7590.964
 CD44v6 (Pos. vs Neg.)1.1680.848–1.6090.340
Model C
 Age less (61 or greater vs than 61)1.4931.100–2.0270.010
 Primary tumor (T) (III/IV vs I/II)2.7651.739–4.395< 0.001
 Lymph nodes metastasis (N) (yes vs no)1.8181.167–2.8330.008
 TNM Stage (III/IV vs I/II)0.8270.461–1.4850.525
 CD44v8-10 (Pos. vs Neg.)1.6941.234–2.3260.001
Model E
 Age less (61 or greater vs than 61)1.5091.112–2.0470.008
 Primary tumor (T) (III/IV vs I/II)2.4111.545–3.764< 0.001
 Lymph nodes metastasis (N) (yes vs no)1.7241.104–2.6910.017
 TNM stage (III/IV vs I/II)0.9550.539–1.6930.875
 ALDH1A1 (high vs low)0.8670.636–1.1820.366
  1. TNM size of primary tumor-node metastasis-distant metastasis, CD44 cluster of differentiation 44, CD44v CD44 variant, ALDH1A1 aldehyde dehydrogenase 1A1, Neg negative expression, Pos positive expression