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Table 1 Clinicopathological characteristics of CCA patients and the correlation with 6 putative CSC marker expression

From: Overexpression of a panel of cancer stem cell markers enhances the predictive capability of the progression and recurrence in the early stage cholangiocarcinoma

Variablesn (178)CD44pCD44v6pCD44v8-10pCD133pEpCAMpALDH1A1p
LowHighNeg.Pos. Neg.Pos.Neg.Pos.LowHighLowHigh
Sex
 Female642935 3331 3133 3727 2836 3430 
 Male11433810.02878360.02672420.05677370.19457570.42360540.950
Age (year)
 Less than 61853352 5431 4936 5431 4441 4342 
 61 or greater9329640.28557360.75854390.95560330.89141520.30651420.570
Tumor site
 Intrahepatic963363 4947 5244 5442 4056 4848 
 Extrahepatic8229530.89062200.00151310.28060220.01945370.07946360.417
Histology type
 Papillary833251 5330 4637 5528 3746 4043 
 Others9530650.33058370.70057380.53759360.56448470.42854410.249
Primary tumor (T)
 I, II1094465 7534 6544 7039 5158 5356 
 III, IV691851 0.05136330.0263831 0.5484425 0.95134350.7464128 0.160
Lymph nodes (N) metastasis
 No1063967 7630 6640 6838 5254 4561 
 Yes7223490.50535370.00237350.14946260.97133390.67349230.001
Distant metastasis (M)
 No17459115 10767 10272 11262 8391 9084 
 Yes4310.088400.116130.178220.554220.92740 0.056
TNM stage
 I, II803248 5921 5129 5129 4040 3248 
 III, IV9830680.19152460.00552460.15163350.94145530.5886236 0.002
  1. CD44 cluster of differentiation 44, CD44v CD44 variant, CD133 cluster of differentiation 133, EpCAM epithelial cell adhesion molecules, ALDH1A1 aldehyde dehydrogenase 1A1, TNM primary tumor-node-metastasis, Neg negative expression, Pos positive expression