Table 1 Histological findings in urinary bladder
Strain | BBN treatment | Period (week) | Effective no. of mice | NMIBC | MIBC | |
|---|---|---|---|---|---|---|
Carcinoma in situ | Ta and T1 | |||||
Wild type | No | 8 | 4 | 0 | 0 | 0 |
12 | 4 | 0 | 0 | 0 | ||
16 | 5 | 0 | 0 | 0 | ||
20 | 15 | 0 | 0 | 0 | ||
PAI-1 KO | No | 8 | 5 | 0 | 0 | 0 |
12 | 4 | 0 | 0 | 0 | ||
16 | 4 | 0 | 0 | 0 | ||
20 | 16 | 0 | 0 | 0 | ||
Wild type | Yes | 8 | 6 | 6 (100)* | 0 | 0 |
12 | 5 | 5 (100) | 0 | 0 | ||
16 | 6 | 4 (67) | 1 (17) | 1 (17) | ||
20 | 16 | 6 (38) | 2 (13) | 8 (50) | ||
PAI-1 KO | Yes | 8 | 5 | 5 (100) | 0 | 0 |
12 | 4 | 4 (100) | 0 | 0 | ||
16 | 5 | 4 (80) | 1 (20) | 0 | ||
20 | 13 | 2 (15) | 5 (38) | 6 (46) | ||