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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model

Fig. 4

Global gene expression analysis identified key genes that were changed by BBN treatment in PAI-1 KO mice. a Whole genome expression profile evaluated by microarray analysis assessed the expression of 41,345 gene transcripts. Gene expression microarray heatmap (n = 2 per group) of dysregulated genes. b Strategy for gene selection. Since PAI-2 is upregulated by BBN but PAI-1 deficiency further upregulated PAI-2, we first compare between control and BBN in WT and PAI-1 KO mice, respectively. Then we identified common genes that are found in both WT and PAI-1 KO mice. With the common genes, we selected further up- or down-regulated genes. c Gene interaction map with 9 most upregulated and 9 most downregulated genes along with PAI-1 and PAI-2. d Pathway analysis of the genes identified in c

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