Fig. 2

Development of CIS, NMIBC and MIBC in WT and PAI-1 KO mice. H&E staining of bladder urothelium from 3 untreated, aged WT mice (26–28 weeks old); bladder urothelium from 3 WT mice with CIS after 8 weeks of BBN exposure; bladder urothelium from 3 WT mice with CIS after 12 weeks of BBN exposure; bladder urothelium from 3 WT mice with CIS and NMIBC after 16 weeks of BBN exposure; bladder urothelium from 3 WT mice with NMIBC and MIBC after 20 weeks of BBN exposure; 3 untreated, aged PAI-1 KO mice (26–28 weeks old); bladder urothelium from 3 PAI-1 KO mice with CIS after 8 weeks of BBN exposure; bladder urothelium from 3 PAI-1 KO mice with CIS after 12 weeks of BBN exposure; bladder urothelium from 3 PAI-1 KO mice with CIS and NMIBC after 16 weeks of BBN exposure; bladder urothelium from 3 PAI-1 KO mice with NMIBC and MIBC after 20 weeks of BBN exposure. All normal CIS images were captured at 400× magnification and all tumor images were captured at 100× magnification