Fig. 2

Changes in total serum protein, angiopoietins, and soluble TIE2 during major gynecological abdominal tumor surgery. Serum was sampled before beginning of surgery (baseline), intraoperatively every 5 L of administered fluids, and postoperatively. In samples, total serum protein as well as levels of ANG-1, -2, and soluble TIE2 were determined. Figure shows absolute values for baseline, 5 L, and postoperative time point. a Changes in total serum protein are given on the left panel. Middle panel shows the distribution of percentage total serum protein decrease in the whole cohort after 5 L of fluid administration. On the right panel, the association between individual percentage total serum protein decrease after 5 L of fluid administration and the postoperative fluid balance is shown (Spearman rank correlation, dashed lines indicate the 95% confidence interval). b Graphs show changes in ANG-1, -2, the ratio between ANG-2 and -1, and sTIE2. Wilcoxon signed-rank test, *** p < 0.001. Changes of serum parameters over time are shown as absolute values with median