Fig. 4

Putative TME-derived circulating miRNA associated with good prognosis in metastatic melanoma. Kaplan–Meier curves for 5-year overall survival rate of melanoma patients from G2 and G3 according to High (≥ average expression) or Low (< average expression) expression of a mir-150 (p = 0.012, log-rank test) and bHILPDA (p = 0.045, log-rank test). c Violin plot showing the expression of HILPDA by cell type based on melanoma SCRS data. The malignant cell type was used as reference for MW test. d Boxplots of miR-150-5p expression levels (log 10 normalized beta values) in extracellular vesicles extracted from plasma samples. MW test was used to compare pairwise means from all groups. **p ≤ 0.01, ***p ≤ 0.001 and ****p ≤ 0.0001