Table 1 Selected cases of modified MSCs application and therapeutic outcome
From: Improved therapeutics of modified mesenchymal stem cells: an update
Modification element | Condition | Results | References |
|---|---|---|---|
Decorin | Radiation-induced lung injuries | ↓Lymphocyte infiltration and apoptosis ↑Proliferation of epithelial cells and inhibition of fibrosis Effective induction of interferon-γ expression and inhibition of collagen type III α1 expression | [118] |
miRNA | Lung fibrosis | Distinctive expression in cytokines and CD45-positive cells Quick weight gain and improved survival rate | [121] |
CCR1 | Injured myocardium | Augmented cell survival, migration and engraftment Significant reduction in infarct size, reduced cardiomyocytes apoptosis and increased capillary density in injured myocardium Inhibited cardiac remodeling and restored cardiac function 4 weeks after injury | [21] |
Betacellulin | Hyperglycemia | Increased insulin production levels Ameliorated hyperglycemia | [131] |
Deferoxamine | Diabetes | Upregulation of CXCR4/CCR2 and higher activity of MMP-2/MMP-9 Increase migration and subsequent homing | [85] |
Sox11 | Bone fracture | Increased differentiation, migration, and viability of MSCs under oxidative stress | [104] |
Activate of BMP/Smad signaling pathway, Runx2, and CXCR4 Accelerating bone fracture healing | |||
ACE2 | Injured endothelium | Decreased inflammatory mediators, reduced paracellular permeability, and enhanced survival of endothelial cells Restore endothelial function | [108] |
Integrin α4 | Cerebral embolism (stroke) | Increased transendothelial migration of MSCs Decreased cell aggregation and ameliorated evoked cerebral embolism in stroke rats | [105] |
miR‐122 | Liver fibrosis | Suppressed the proliferation of and collagen maturation in HSCs Enhanced the therapeutic efficacy of MSCs | [106] |