Skip to main content

Table 1 Functional roles of hub genes with a degree ≥ 10

From: Bioinformatics-based screening of key genes for transformation of liver cirrhosis to hepatocellular carcinoma

Gene symbol Full name Function
CDKN3 Cyclin-dependent kinase inhibitor 3 The protein was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with and dephosphorylate CDK2 kinase, thereby preventing the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers
CYP2C9 Cytochrome P450 family 2 subfamily C member 9 This gene encodes a member of the cytochrome P450 superfamily of enzymes. These monooxygenases catalyse many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids
LCAT Lecithin-cholesterol acyltransferase This gene encodes the extracellular cholesterol esterifying enzyme lecithin-cholesterol acyltransferase. Esterification of cholesterol is required for cholesterol transport