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Table 1 Functional roles of hub genes with a degree ≥ 10

From: Bioinformatics-based screening of key genes for transformation of liver cirrhosis to hepatocellular carcinoma

Gene symbolFull nameFunction
CDKN3Cyclin-dependent kinase inhibitor 3The protein was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with and dephosphorylate CDK2 kinase, thereby preventing the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers
CYP2C9Cytochrome P450 family 2 subfamily C member 9This gene encodes a member of the cytochrome P450 superfamily of enzymes. These monooxygenases catalyse many reactions involved in drug metabolism and the synthesis of cholesterol, steroids and other lipids
LCATLecithin-cholesterol acyltransferaseThis gene encodes the extracellular cholesterol esterifying enzyme lecithin-cholesterol acyltransferase. Esterification of cholesterol is required for cholesterol transport