Fig. 1

Venn diagram and PPI network analyses, showing the most significant module related to DEGs. a DEGs were identified from GSE17548, GSE63898, GSE54238 and GSE89377 gene expression profiling datasets based on fold change > 2 and adjusted p value < 0.05. The four datasets share 58 overlapping DEGs. b PPI network constructed using 58 DEGs. Up- and down-regulated genes were marked in red and blue, respectively. c The most significant module of the PPI network includes 12 nodes and 66 edges