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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: C-reactive protein derived from perivascular adipose tissue accelerates injury-induced neointimal hyperplasia

Fig. 2

Overexpression of CRP in PVAT promoted neointimal hyperplasia, adventitial macrophage infiltration, and vasa vasorum proliferation at 4 weeks after endovascular injury. a Representative H&E-stained sections of femoral arteries after endovascular injury in STD-fed mice transplanted with WT PVAT or CRPTG PVAT. Arrows indicate internal elastic lamina. b CD68 (macrophage marker) staining revealed transplanted CRPTG PVAT markedly increased the numbers of adventitial macrophages surrounding injured arteries. Red arrows indicate CD68+ cells. c CD31 (endothelial cell marker, representative of vessels) staining showed transplanted CRPTG PVAT significantly increased adventitial adjacent to the injured vessel. Red arrows indicate CD31+ cells. Scale bars, 100 μm, *P < 0.05 versus WT PVAT transplantation. Data represent mean ± SE (n = 6)

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