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Table 2 10 metabolic biomarkers of rhythmic disorder in control and model groups

From: Establishment of the circadian metabolic phenotype strategy in spontaneously hypertensive rats: a dynamic metabolomics study

No.NameFormulaRetention time[M + H]+[M − H]-p-value (m/z)VIPMax (min) peak area/time (control)Max (min) peak area/time (model)Metabolic pathway
1OrnithineC5H12N2O20.626133.09711.98E−061.6841,548,032,8389:00–11:002,009,357,54821:00–23:00Urea cycle, arginine and proline metabolism
2GlutamineC5H9NO40.768148.06044.91E−071.580215,800,083.49:00–11:00313,690,052.113:00–15:00Urea cycle
3Indoleacetic acidC10H9NO25.837176.07061.95E−101.77839,250,248.655:00–7:00139,699,738.513:00–15:00Tryptophan metabolism
4CitrullineC6H13N3O30.761176.10291.28E−131.42139,030,378.9717:00–19:0062,299,687.795:00–7:00Urea cycle, arginine and proline metabolism
5SerotoninC10H12N2O1.331177.10227.58E−141.616250,880,110.69:00–11:00436,645,654.411:00–13:00Tryptophan metabolism
6l-KynurenineC10H12N2O31.728209.09201.91E−081.74068,395,431.467:00–9:0036,004,712.7411:00–13:00Tryptophan metabolism
7d-ProlineC5H9NO20.782116.07060.0021.262847,981,62417:00–19:00964,359,024.521:00–23:00Arginine and proline metabolism
82-Oxoglutaric acidC5H6O50.796145.01421.66E−061.43970,400,138.9517:00–19:00242,316,284.819:00–21:00Urea cycle, arginine and proline metabolism, tryptophan metabolism
9CreatineC4H9N3O20.746132.07675.88E−091.51921,817,421,9509:00–11:0027,898,769,67321:00–23:00Arginine and proline metabolism
105-HydroxytryptophanC11H12N2O33.14221.09201.76E−121.41943,687,663.2419:00–21:0032,068,942.0915:00–17:00Tryptophan metabolism