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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: Establishment of the circadian metabolic phenotype strategy in spontaneously hypertensive rats: a dynamic metabolomics study

Fig. 4

Total ion chromatogram of serum was collected by mass spectrometry under positive and negative ion modes (a: positive; b: negative). Amino acids were mostly collected in the positive ion mode. c, d The extracted ion currents of 10 markers, and most substances peaked within 5 min. e, f The 24-h trend charts of 10 metabolites and metabolic pathways. The amplitude and expression of the model group and the control group are different at 24 h, in which ornithine, citrulline, creatine and 5-hydroxytryptophan have opposite trends. Zeitgeber time (ZT) 0 represents lights on. The metabolic pathways included glycolysis, urea metabolism, the TCA, tyrosine metabolism, and tryptophan metabolism

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