Fig. 1

Heat map representation and pathway analysis of the differentially expressed genes in the mesenteric adipose tissue (MAT) and ileal mucosa of Crohn’s disease (CD) compared to the respective control (CTR) groups based on RNA sequencing. For the CD group, n = 8. For the CTR group, n = 4. a, c Each line represents one individual gene, and each column an experimental sample. Differentially upregulated genes are shown in red and downregulated genes are shown in green. Based on the number of sequences identified by each gene in the CTR and CD groups, it was possible to quantify the expressed genes using the RSEM tool v.1.2.31. b Canonical pathways significantly regulated genes in the MAT of CD patients are shown in a polar plot representing the − log(p-value) of each pathway association. The analysis was based on Ingenuity Pathway Analysis (IPA) Software (QIAGEN Inc., https://www.qiagenbioinformatics.com/products/ingenuity-pathway-analysis). d Polar plots representing the most significantly regulated canonical pathways in the ileal mucosa of CD patients. The analysis was based on Ingenuity Pathway Analysis (IPA). The − log(p-value) of each pathway association is shown