Prostanoid receptor genes confer poor prognosis in head and neck squamous cell carcinoma via epigenetic inactivation

Table 1 Distribution of methylation status by selected epidemiologic and clinical characteristics

Gene	Methylation status	Characteristics	Age			Gender			Smoking status			Alcohol exposure
Gene	Methylation status	Overall (%)	< 65	> 65	P^†	Female	Male	P^†	Smoker	Non smoker	P^†	Drinker	Non drinker	P^†
PTGDR1	Yes	120 (43.8)	50	70		16	104		97	23		97	23
PTGDR1	No	154 (56.2)	63	91	1	31	123	0.149	111	43	0.117	112	42	0.152
PTGDR2	Yes	50 (18.2)	16	34		7	43		42	8		44	6
PTGDR2	No	224 (81.8)	97	127	0.156	40	184	0.678	166	58	0.199	165	59	0.042*
PTGER1	Yes	70 (25.5)	30	40		8	62		55	15		60	10
PTGER1	No	204 (74.5)	83	121	1	39	165	0.197	153	51	0.628	149	55	0.034*
PTGER2	Yes	48 (17.5)	18	30		10	38		37	11		39	9
PTGER2	No	226 (82.5)	95	131	0.630	37	189	1	171	55	1	170	56	0.457
PTGER3	Yes	113 (41.2)	49	64		17	96		87	26		86	27
PTGER3	No	161 (58.8)	64	97	1	30	131	0.516	121	40	0.775	123	38	1
PTGER4	Yes	22 (8.0)	6	16		4	18		18	4		18	4
PTGER4	No	252 (92.0)	107	145	0.183	43	209	1	190	62	0.610	191	61	0.612
PTGFR	Yes	53 (19.3)	15	38		8	45		44	9		46	7
PTGFR	No	221 (80.7)	98	123	0.043*	39	182	0.839	164	57	0.212	163	58	0.049*
PTGIR	Yes	56 (20.4)	20	36		8	48		46	10		48	8
PTGIR	No	218 (79.6)	93	125	0.366	39	179	0.691	162	56	0.293	161	57	0.078
TBXA2R	Yes	31 (11.3)	10	21		4	27		27	4		27	4
TBXA2R	No	243 (88.7)	103	140	0.355	43	200	0.620	181	62	0.179	182	61	0.346

Gene	Tumor size			Lympho-node status			Stage			HPV status			Recurrence events
Gene	T1–2	T3–4	P^†	N0	N+	P^†	I, II	III, IV	P^†	Negative	Positive	P^†	Negative	Positive	P^†
PTGDR1	54	66		47	73		24	36		105	15		47	68
PTGDR1	80	74	0.274	61	93	1	96	118	0.557	95	36	0.004*	127	32	< 0.001*
PTGDR2	23	27		16	34		9	51		44	6		22	27
PTGDR2	111	113	0.755	92	132	0.265	41	173	0.572	156	45	0.118	152	73	0.005*
PTGER1	30	40		27	43		15	45		59	11		29	40
PTGER1	104	100	0.269	81	123	0.888	55	159	1	141	40	0.297	145	60	< 0.001*
PTGER2	21	27		19	29		10	50		42	6		19	28
PTGER2	113	113	0.525	89	137	1	38	176	1	158	45	0.164	155	72	< 0.001*
PTGER3	52	61		43	70		23	37		99	14		38	72
PTGER3	82	79	0.462	65	96	0.708	90	124	0.658	101	37	0.005*	136	28	< 0.001*
PTGER4	11	11		12	10		6	54		20	2		9	13
PTGER4	123	129	1	96	156	0.172	16	198	1	180	49	0.266	165	87	0.035*
PTGFR	26	27		19	34		12	48		46	7		22	31
PTGFR	108	113	1	89	132	0.639	41	173	1	154	44	0.180	152	69	< 0.001*
PTGIR	28	28		16	40		9	51		48	8		24	32
PTGIR	106	112	1	92	126	0.067	47	167	0.280	152	43	0.259	150	68	< 0.001*
TBXA2R	10	21		13	18		7	53		27	4		16	15
TBXA2R	124	119	0.057	95	148	1	24	190	1	173	47	0.346	158	85	1

ISSN: 1479-5876