Fig. 3

Invasion of meningeal tumors into the cerebrum. a GFP-stained histological preparations of the meningeal-cerebral border in untreated and bevacizumab-treated mice showing that A-07 and D-12 meningeal tumors invaded the cerebral parenchyma and developed micrometastases. b Adjacent GFP-stained, HE-stained, and CD31-stained histological preparations showing two cerebral A-07 micrometastases (arrows) supplied by a central co-opted vessel. c The density of A-07 cerebral micrometastases was higher in bevacizumab-treated mice than in untreated mice and correlated with host survival time, whereas the density of D-12 cerebral micrometastases did not differ between untreated and bevacizumab-treated mice and was independent of host survival time. Columns: mean of 5 tumors. Bars: standard error. Points: individual mice. Curve: linear regression. P-values: two-sided t-test (left panel) or Spearman rank order test (middle panel)