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Fig. 2 | Journal of Translational Medicine

Fig. 2

From: Selenium-binding protein 1 transcriptionally activates p21 expression via p53-independent mechanism and its frequent reduction associates with poor prognosis in bladder cancer

Fig. 2

Visualization of the association between SELENBP1 expression and DNA methylation in TCGA-BLCA cohort using the MEXPRESS tool. SELENBP1 gene together with its transcripts is indicated in the left bottom panel. Next to the gene, blue line plots show the methylation data for the location of each probe (Infinium Human Methylation 450 microarray data; infinium 450 k), whose relative location in SELENBP1 gene is also indicated in the far right panel. The yellow line plot displays the RNA-seq-derived expression data, and the samples are ordered by SELENBP1 expression value. This view shows how SELENBP1 expression and DNA methylation in different parts of SELENBP1 gene are correlated, which is confirmed by the Pearson correlation test. The correlation coefficients (r) are indicated in the right panel. The symbol (***) shows a significant correlation (p < 0.001). TSS, transcription start site; UTR, untranslated region

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