Transcriptome analysis defines myocardium gene signatures in children with ToF and ASD and reveals disease-specific molecular reprogramming in response to surgery with cardiopulmonary bypass

Table 6 Hypoxia-related gene sets enriched in Post- vs Pre-CPB ASD samples

GSEA term^a	NOM p-val^b	FDR q-val^c
GROSS_ELK3_TARGETS_DN	0.002	0.012
CHEN_LVAD_SUPPORT_OF_FAILING_HEART_UP	0.018	0.014
BIOCARTA_CARDIACEGF_PATHWAY	0.002	0.014
LEONARD_HYPOXIA	0.002	0.011
GROSS_HYPOXIA_VIA_ELK3_DN	0.026	0.030
GROSS_HYPOXIA_VIA_ELK3_ONLY_UP	0.016	0.043
MENSE_HYPOXIA_UP	0.012	0.042
KRIEG_HYPOXIA_VIA_KDM3A	0.042	0.095
HARRIS_HYPOXIA	0.053	0.096
HU_ANGIOGENESIS_UP	0.048	0.101
KIM_HYPOXIA	0.050	0.142

Gene sets are ordered according to increasing FDR q-val
^aGene sets enriched in the GSEA analysis. Gene sets belonging to all curated collections o f the MSigDB were selected using the keywords “hypoxia” and “heart” and filtering out those having less than 15 probe sets and more than 500 probe sets
^bNOM p-val measures the statistical significance of the normalized enriched score by an empirical permutation test using 1.000 gene permutations. NOM p-val ≤ 0.05 are considered significant
^cFDR q-value is the estimated probability that the normalized enrichment s core represents a false positive finding. Values ≤ 0.2 are considered significant

ISSN: 1479-5876