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Table 4 Relative expression of genes selectively modulated in Post- vs Pre-CPB ToF samples

From: Transcriptome analysis defines myocardium gene signatures in children with ToF and ASD and reveals disease-specific molecular reprogramming in response to surgery with cardiopulmonary bypass

Function

Gene symbol

Gene description

Fold changea

Transcription regulation

IRF1

Interferon regulatory factor 1

10.3

BHLHE40

Basic helix-loop-helix family, member e40

4.4

MIR612/NEAT1

MicroRNA 612/ nuclear paraspeckle assembly transcript 1

3.7

KLF10

Kruppel-like factor 10

3.1

BCL3/MIR8085

B-cell CLL/lymphoma 3/microRNA 8085

3.1

IFRD1

Interferon-related developmental regulator 1

2.9

DDIT3

DNA-damage-inducible transcript 3

2.7

SOX9

SRY (sex determining region Y)-box 9

2.5

ETS2

v-ets avian erythroblastosis virus E26 oncogene homolog 2

2.4

CEBPB

CCAAT/enhancer binding protein (C/EBP), beta

2.1

CEBPD

CCAAT/enhancer binding protein (C/EBP), delta

2.0

AFF4

AF4/FMR2 family, member 4

2.0

Inflammatory responses

CXCL8

Chemokine (C-X-C motif) ligand 8

19.6

IL6

Interleukin 6

18.7

AREG

Amphiregulin

10.1

TNFAIP3

Tumor necrosis factor, alpha-induced protein 3

3.0

IL1RL1

Interleukin 1 receptor-like 1

2.8

SQSTM1

Sequestosome 1

2.7

HSPA1A,1B

Heat shock 70kDa protein 1A,1B

2.2

KDM6B

Lysine (K)-specific demethylase 6B

2.0

C1QC

Complement component 1, q subcomponent, C chain

0.5

C1QB

Complement component 1, q subcomponent, B chain

0.4

Cell adhesion, cytoskeleton and matrix organization

ABRA

Actin-binding Rho activating protein

8.5

THBS1

Thrombospondin 1

7.9

PDLIM3

PDZ and LIM domain 3

5.3

MMP19

Matrix metallopeptidase 19

4.6

FBN2

Fibrillin 2

2 4

XIRP1 (CMYA1)

Xin actin-binding repeat containing 1

3.6

HBEGF

Heparin-binding EGF-like growth factor

2.6

CTNNB1

Catenin (cadherin-associated protein), beta 1, 88 kDa

2

Antioxidant activity

MT1X

Metallothionein 1X

3.9

MT1F

Metallothionein 1F

3.1

MT1HL1

Metallothionein 1H-like 1

3.1

MT1H

Metallothionein 1H

2.9

MT1E

Metallothionein 1E

2.9

MT1G

Metallothionein 1G

2.5

DNA repair

SPIDR

Scaffolding protein involved in DNA repair

5.5

PPP1R10

Protein phosphatase 1, regulatory subunit 10

2.1

  1. Comparative analysis of gene expression in Pre-CPB and Post-CPB ToF samples was conducted as described in “Methods” section. A main function, a gene symbol, a brief gene description, and the fold change values are specified for each gene
  2. Genes for each functional category are ordered according to decreasing fold changes
  3. aFold change was calculated as the ratio between the mean expression value of Post-ToF and Pre-ToF samples for each gene. Fold changes ≥ 2 or ≤ 0.5 are considered significant
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Journal of Translational Medicine

ISSN: 1479-5876

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