Transcriptome analysis defines myocardium gene signatures in children with ToF and ASD and reveals disease-specific molecular reprogramming in response to surgery with cardiopulmonary bypass

Table 2 Hypoxia-related gene sets enriched in ToF vs ASD samples

GSEA term^a	NOM p-val^b	FDR q-val^c
BIOCARTA_AMI_PATHWAY	0.00	0.00
FARDIN_HYPOXIA_11	0.00	0.03
IKEDA_MIR30_TARGETS_DN	0.02	0.09
QI_HYPOXIA	0.00	0.14
MAINA_VHL_TARGETS_DN	0.01	0.16
KIM_HYPOXIA	0.02	0.16
MENSE_HYPOXIA_UP	0.02	0.17
ELVIDGE_HYPOXIA_BY_DMOG_UP	0.05	0.18
MANALO_HYPOXIA_UP	0.02	0.18
ELVIDGE_HIF1A_AND_HIF2A_TARGETS_DN	0.01	0.19
JIANG_HYPOXIA_VIA_VHL	0.04	0.19
HARRIS_HYPOXIA	0.04	0.19
ELVIDGE_HIF1A_TARGETS_DN	0.00	0.19
LEONARD_HYPOXIA	0.04	0.20

Gene sets are ordered according to increasing FDR q-val
^aGene sets enriched in the GSEA analysis. Gene sets belonging to all curated collections of the MSigDB were selected using the keywords “hypoxia” and “heart” and filtering out those having less than 15 probe sets and more than 500
^bNOM p-val measures the statistical significance of the normalized enriched score by an empirical permutation test using 1.000 gene permutations. Values ≤ 0.05 are considered significant
^cFDR q-value is the estimated probability that the normalized enrichment score represents a false positive finding. Values ≤ 0.2 are considered significant

ISSN: 1479-5876