Fig. 5

DEGs functional enrichment/network analyses in Post-CPB vs Pre-CPB atrial samples from ToF and ASD patients. a GO enrichment analysis. Genes showing at least twofold expression changes between Post-CPB and Pre-CPB conditions were analyzed using the GO biological processes collection, as detailed in the legend of Fig. 2a. The graph shows the most relevant GO terms. The GO term name is reported on the y-axis; the number of enriched DEGs for each term is indicated on the x-axis. The blue columns represent DEGs modulated in ToF patients; the red columns represent DEGs modulated in ASD patients. GO terms are listed by decreasing number of DEGs in ToF samples. The p value for each GO term is indicated. b Network analysis. Functional interaction networks among DEGs products were constructed using the STRING-DB software as detailed in the legend of Fig. 2b. Networks are displayed graphically as nodes (DEGs products) and edges (predicted protein–protein associations). Only associations with a high degree of confidence (0.7) are displayed in the plot