TY - JOUR AU - Raggi, Federica AU - Cangelosi, Davide AU - Becherini, Pamela AU - Blengio, Fabiola AU - Morini, Martina AU - Acquaviva, Massimo AU - Belli, Maria Luisa AU - Panizzon, Giuseppe AU - Cervo, Giuseppe AU - Varesio, Luigi AU - Eva, Alessandra AU - Bosco, Maria Carla PY - 2020 DA - 2020/01/10 TI - Transcriptome analysis defines myocardium gene signatures in children with ToF and ASD and reveals disease-specific molecular reprogramming in response to surgery with cardiopulmonary bypass JO - Journal of Translational Medicine SP - 21 VL - 18 IS - 1 AB - Tetralogy of Fallot (ToF) and Atrial Septal Defects (ASD) are the most common types of congenital heart diseases and a major cause of childhood morbidity and mortality. Cardiopulmonary bypass (CPB) is used during corrective cardiac surgery to support circulation and heart stabilization. However, this procedure triggers systemic inflammatory and stress response and consequent increased risk of postoperative complications. The aim of this study was to define the molecular bases of ToF and ASD pathogenesis and response to CPB and identify new potential biomarkers. SN - 1479-5876 UR - https://doi.org/10.1186/s12967-020-02210-5 DO - 10.1186/s12967-020-02210-5 ID - Raggi2020 ER -