From: Immunotherapy Bridge 2019 and Melanoma Bridge 2019: meeting abstracts
 | NO IPI (10 pts) | RT POST IPI (15 pts) | RT CONC IPI (20 pts) | RT PRE IPI (18 pts) | TOTAL (63 pts) | |
---|---|---|---|---|---|---|
Sex | M | 7 | 5 | 9 | 13 | 34 |
F | 3 | 10 | 11 | 5 | 29 | |
Age | Years | |||||
Median | 64 | 62 | 55 | 63 | 60 | |
Range | 40–77 | 29–81 | 28–80 | 32–80 | 28–81 | |
ECOG PS | 0 | 8 | 14 | 17 | 14 | 53 |
1 | 2 | 1 | 3 | 4 | 10 | |
RPA | Class I | 0 | 0 | 1 | 3 | 4 |
Class II | 10 | 15 | 19 | 15 | 59 | |
DS-GPA | 1 | 0 | 0 | 0 | 0 | 0 |
2 | 1 | 3 | 3 | 0 | 7 | |
3 | 4 | 6 | 7 | 10 | 27 | |
4 | 5 | 6 | 10 | 8 | 29 | |
Melanoma site | Cutaneous | 8 | 14 | 18 | 17 | 57 |
Mucosal | 1 | 1 | 1 | 0 | 3 | |
Unknown | 1 | 0 | 0 | 1 | 2 | |
Ocular | 0 | 0 | 1 | 0 | 1 | |
Time between diagnosis and BMs | Months | Â | Â | Â | Â | Â |
Median | 34 | 37 | 23 | 34 | 34 | |
Range | 0–192 | 0–240 | 0–228 | 3–240 | 0–240 | |
Extracranial disease | Yes | 6 | 23 | 6 | 14 | 49 |
No | 5 | 1 | 1 | 7 | 14 | |
LDH pre-RT | Normal | 4 | 9 | 11 | 9 | 33 |
High | 4 | 5 | 7 | 6 | 22 | |
NA | 2 | 1 | 2 | 3 | 8 | |
BRAF status | Mutated | 8 | 5 | 7 | 9 | 29 |
Wild tipe | 2 | 10 | 13 | 8 | 33 | |
NA | Â | Â | Â | 1 | 1 | |
Neurological symptoms | Asymptomatic | 5 | 15 | 14 | 14 | 48 |
Symptomatic | 5 | 0 | 6 | 4 | 15 | |
Steroid treatment pre-RT | Yes | 5 | 5 | 7 | 9 | 26 |
No | 4 | 8 | 13 | 9 | 34 | |
NA | 1 | 2 | – | – | 3 | |
Number of BMs treated | Â | 16 | 34 | 38 | 39 | 127 |
Lesion size | Median (mm) | 9 | 9 | 8 | 8 | 8 |
Range (mm) | 2–30 | 3–36 | 2–42 | 3–37 | 2–42 | |
0–2 (cm) | 13 | 28 | 33 | 31 | 105 | |
> 2–< 3 (cm) | 3 | 3 | 3 | 7 | 16 | |
> 3 (cm) | 0 | 2 | 2 | 1 | 5 | |
NA | – | 1 | – | – | 1 | |
Radiation Treatment | SRS (dose range 10–24 Gy) | 11 | 20 | 21 | 21 | 75 |
SRT (dose range 18–24 Gy) | 4 | 4 | 6 | 10 | 24 | |
Treatments before CK SRS/SRT | SRS | 0 | 1 | 0 | 0 | 1 |
WBRT | 2 | 2 | 0 | 1 | 5 | |
Surgery | 5 | 0 | 0 | 1 | 6 | |
Treatments after CK SRS/SRT | SRS/SRT* | 3# | 7 | 7 | 8 | 25 |
WBRT | 0 | 4 | 4 | 7 | 15 | |
Surgery | 1 | 0 | 0 | 1 | 2 |