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Table 4 Genes and variants identified from the gene-score analysis step for osteoporosis BRONJ cases

From: Identifying genetic variants underlying medication-induced osteonecrosis of the jaw in cancer and osteoporosis: a case control study

No.GenesVariants
HugoGene nameGene scorep valueChrPosRef/AltSIFT/CADDAFp value
CaseControlCase/Control
1CDC27Cell division cycle 270.46 ± 0.490.97 ± 0.18< 0.001chr1745,214,654C/T0/20.60.22/0.010.000
2DFFADNA fragmentation factor subunit alpha0.80 ± 0.410.94 ± 0.230.022chr110,521,569C/T0/7.6650.10/0.030.042
3FAM193AFamily with sequence similarity 193 member A0.79 ± 0.380.95 ± 0.180.009chr42,632,766C/T0.02/12.710.08/0.010.008
4TNRC18Trinucleotide repeat containing 180.73 ± 0.240.89 ± 0.22< 0.001chr75,427,467G/A0.01/16.780.08/0.010.008
5VEGFAVascular endothelial growth factor A0.88 ± 0.330.98 ± 0.130.033chr643,752,346C/A0/14.640.06/0.010.033
  1. AF allele frequency