Table 3 Genes and variants identified from the gene-score analysis step for cancer BRONJ cases
No. | Genes | Variants | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Hugo | Gene name | Gene score | p value | Chr | Pos | Ref/Alt | SIFT/CADD | AF | p value | ||
Case | Control | Case/control | |||||||||
1 | ARID2 | AT-rich interaction domain 2 | 0.41 ± 0.49 | 0.83 ± 0.83 | < 0.001 | chr12 | 46,246,206 | G/T | 0.02/15.55 | 0.23/0.07 | 0.015 |
2 | CDC27 | Cell division cycle 27 | 0.69 ± 0.48 | 0.97 ± 0.18 | < 0.001 | chr17 | 45,214,654 | C/T | 0/20.6 | 0.15/0.01 | 0.003 |
3 | HEBP1 | Heme-binding protein 1 | 0.77 ± 0.44 | 0.98 ± 0.15 | 0.001 | chr12 | 13,128,263 | C/G | 0/20.1 | 0.12/0.01 | 0.015 |
4 | LTBP1 | Latent transforming growth factor beta-binding protein 1 | 0.52 ± 0.43 | 0.81 ± 0.24 | 0.018 | chr2 | 33,505,139 | C/A | 0/32 | 0.15/0.03 | 0.016 |
5 | PLVAP | Plasmalemma vesicle-associated protein | 0.81 ± 0.37 | 0.96 ± 0.16 | 0.029 | chr19 | 17,476,328 | G/A | 0.01/6.50 | 0.08/0.01 | 0.043 |
6 | TNRC18 | Trinucleotide repeat containing 18 | 0.73 ± 0.27 | 0.89 ± 0.22 | 0.003 | chr7 | 5,427,467 | G/A | 0.01/16.78 | 0.08/0.01 | 0.043 |