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Table 3 Genes and variants identified from the gene-score analysis step for cancer BRONJ cases

From: Identifying genetic variants underlying medication-induced osteonecrosis of the jaw in cancer and osteoporosis: a case control study

No.GenesVariants
HugoGene nameGene scorep valueChrPosRef/AltSIFT/CADDAFp value
CaseControlCase/control
1ARID2AT-rich interaction domain 20.41 ± 0.490.83 ± 0.83< 0.001chr1246,246,206G/T0.02/15.550.23/0.070.015
2CDC27Cell division cycle 270.69 ± 0.480.97 ± 0.18< 0.001chr1745,214,654C/T0/20.60.15/0.010.003
3HEBP1Heme-binding protein 10.77 ± 0.440.98 ± 0.150.001chr1213,128,263C/G0/20.10.12/0.010.015
4LTBP1Latent transforming growth factor beta-binding protein 10.52 ± 0.430.81 ± 0.240.018chr233,505,139C/A0/320.15/0.030.016
5PLVAPPlasmalemma vesicle-associated protein0.81 ± 0.370.96 ± 0.160.029chr1917,476,328G/A0.01/6.500.08/0.010.043
6TNRC18Trinucleotide repeat containing 180.73 ± 0.270.89 ± 0.220.003chr75,427,467G/A0.01/16.780.08/0.010.043
  1. AF allele frequency