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Table 2 Clinical and laboratory characteristics of FH patients at baseline stratified by tertile of baseline PCSK9 concentration

From: Circulating PCSK9 and cardiovascular events in FH patients with standard lipid-lowering therapy

VariablesPCSK9 concentration tertile 
Tertile 1
(< 274 ng/mL)
Tertile 2
(274–369 ng/mL)
Tertile 3
(> 369 ng/mL)
p-value for trend
Clinical factors
Age, years49.11 ± 9.8550.86 ± 12.3048.16± 11.690.193
Male, n (%)78 (69.6)59 (52.2)61 (54.0)0.014
BMI, kg/(m2)25.70 ± 3.5525.74 ± 3.0125.04 ± 3.620.267
Prior CAD, n (%)51 (45.5)61 (54.0)77 (68.1)0.003
Family history of CAD, n (%)52 (46.4)55 (48.7)50 (44.2)0.801
Currently smoking, n (%)49 (43.8)34 (30.1)43 (38.1)0.178
Alcohol drinker, n (%)30 (26.8)31 (27.4)14 (12.4)0.008
Hypertension, n (%)45 (40.2)47 (41.6)42 (37.2)0.747
Diabetes, n (%)23 (20.5)17 (15.0)16 (14.2)0.422
Baseline statin use, n (%)92 (82.1)84 (74.3)87 (77.0)0.359
Tendon xanthoma3 (2.7)5 (4.4)18 (15.9)<0.001
Laboratory factors
TG, mmol/L1.70 (1.34–2.20)1.63 (1.11–2.03)1.53 (1.15–2.12)0.146
TC, mmol/L6.41 ± 1.596.97 ± 2.047.62 ± 2.350.001
HDL-C, mmol/L1.07 ± 0.331.19 ± 0.311.08 ± 0.300.005
LDL-C, mmol/L4.68 ± 1.465.11 ± 1.565.80 ± 2.090.001
ApoA, g/L1.27 ± 0.301.41 ± 0.301.25 ± 0.320.001
ApoB, g/L1.31 ± 0.341.42 ± 0.401.61 ± 0.540.001
Lp(a), mg/dL20.81
(9.71–48.41)
33.86
(14.73–66.05)
46.60
(24.87–81.78)
0.001
hsCRP, mg/L1.58 (0.76–3.55)1.41 (0.702.79)1.58 (0.71–3.42)0.654
FPG, mmol/L5.62 ± 1.765.49 ± 1.395.51 ± 1.320.787
HbA1C,  %6.21 ± 1.226.09 ± 0.986.05 ± 0.920.525
WBC, ng/mL6.30 ± 1.796.21 ± 1.576.48 ± 1.960.556
LYM, ng/mL2.04± 0.702.09± 0.622.04 ± 0.670.832
  1. Data are expressed as mean ± standard deviation, median (interquartile range) or n (%)
  2. FH familial hypercholesterolemia, BMI body mass index, CAD coronary artery disease, TG triglyceride, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA apolipoprotein A, ApoB apolipoprotein B, Lp(a) lipoprotein(a), hsCRP high sensitivity C-reactive protein, FPG fasting plasma glucose, HbA1c glycosylated hemoglobin, WBC white blood cell, LYM lymphocyte