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Table 2 Clinical and laboratory characteristics of FH patients at baseline stratified by tertile of baseline PCSK9 concentration

From: Circulating PCSK9 and cardiovascular events in FH patients with standard lipid-lowering therapy

Variables

PCSK9 concentration tertile

 

Tertile 1

(< 274 ng/mL)

Tertile 2

(274–369 ng/mL)

Tertile 3

(> 369 ng/mL)

p-value for trend

Clinical factors

Age, years

49.11 ± 9.85

50.86 ± 12.30

48.16± 11.69

0.193

Male, n (%)

78 (69.6)

59 (52.2)

61 (54.0)

0.014

BMI, kg/(m2)

25.70 ± 3.55

25.74 ± 3.01

25.04 ± 3.62

0.267

Prior CAD, n (%)

51 (45.5)

61 (54.0)

77 (68.1)

0.003

Family history of CAD, n (%)

52 (46.4)

55 (48.7)

50 (44.2)

0.801

Currently smoking, n (%)

49 (43.8)

34 (30.1)

43 (38.1)

0.178

Alcohol drinker, n (%)

30 (26.8)

31 (27.4)

14 (12.4)

0.008

Hypertension, n (%)

45 (40.2)

47 (41.6)

42 (37.2)

0.747

Diabetes, n (%)

23 (20.5)

17 (15.0)

16 (14.2)

0.422

Baseline statin use, n (%)

92 (82.1)

84 (74.3)

87 (77.0)

0.359

Tendon xanthoma

3 (2.7)

5 (4.4)

18 (15.9)

<0.001

Laboratory factors

TG, mmol/L

1.70 (1.34–2.20)

1.63 (1.11–2.03)

1.53 (1.15–2.12)

0.146

TC, mmol/L

6.41 ± 1.59

6.97 ± 2.04

7.62 ± 2.35

0.001

HDL-C, mmol/L

1.07 ± 0.33

1.19 ± 0.31

1.08 ± 0.30

0.005

LDL-C, mmol/L

4.68 ± 1.46

5.11 ± 1.56

5.80 ± 2.09

0.001

ApoA, g/L

1.27 ± 0.30

1.41 ± 0.30

1.25 ± 0.32

0.001

ApoB, g/L

1.31 ± 0.34

1.42 ± 0.40

1.61 ± 0.54

0.001

Lp(a), mg/dL

20.81

(9.71–48.41)

33.86

(14.73–66.05)

46.60

(24.87–81.78)

0.001

hsCRP, mg/L

1.58 (0.76–3.55)

1.41 (0.702.79)

1.58 (0.71–3.42)

0.654

FPG, mmol/L

5.62 ± 1.76

5.49 ± 1.39

5.51 ± 1.32

0.787

HbA1C,  %

6.21 ± 1.22

6.09 ± 0.98

6.05 ± 0.92

0.525

WBC, ng/mL

6.30 ± 1.79

6.21 ± 1.57

6.48 ± 1.96

0.556

LYM, ng/mL

2.04± 0.70

2.09± 0.62

2.04 ± 0.67

0.832

  1. Data are expressed as mean ± standard deviation, median (interquartile range) or n (%)
  2. FH familial hypercholesterolemia, BMI body mass index, CAD coronary artery disease, TG triglyceride, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, ApoA apolipoprotein A, ApoB apolipoprotein B, Lp(a) lipoprotein(a), hsCRP high sensitivity C-reactive protein, FPG fasting plasma glucose, HbA1c glycosylated hemoglobin, WBC white blood cell, LYM lymphocyte