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Table 2 Comparisons of diagnostic models and individual markers in different groups

From: Translational value of IDH1 and DNA methylation biomarkers in diagnosing lung cancers: a novel diagnostic panel of stage and histology-specificity

Group

Variables

AUC

S.E.

95% CI

p value

Training group (n = 170)

shox2

0.714

0.0398

0.640–0.781

0.0011

ep4

0.67

0.0391

0.594–0.740

< 0.0001

idh1

0.781

0.0385

0.711–0.841

0.0207

panel

0.835

0.033

0.770–0.887

–

Validation group (n = 51)

shox2

0.659

0.0767

0.513–0.786

0.0009

ep4

0.699

0.0684

0.555–0.820

0.0017

idh1

0.755

0.0703

0.615–0.865

0.015

panel

0.905

0.0419

0.790–0.969

–

Whole group (n = 221)

shox2

0.7

0.0351

0.634–0.759

< 0.0001

ep4

0.674

0.0338

0.608–0.735

< 0.0001

idh1

0.78

0.033

0.719–0.833

0.0018

panel

0.856

0.0258

0.803–0.899

–

  1. shox2 short stature homeobox 2 gene, ep4 prostaglandin E2 receptor 4 gene (PTGER4), idh1 isocitrate dehydrogenase 1, AUC area under the curve, S.E. standard error, 95% CI 95% confidence interval