Translational value of IDH1 and DNA methylation biomarkers in diagnosing lung cancers: a novel diagnostic panel of stage and histology-specificity

Table 1 Basic information

Variables	Training group	Validation group	Whole group
Variables	(n = 170)	(n = 51)	(n = 221)
Sex
Male	71	31	102
Female	99	20	119
Age
≤ 60	125	39	164
> 60	45	12	57
Tumor size
≤ 5 cm	94	29	123
> 5 cm	21	6	27
Pathology
Ade	90	22	112
SCC	14	5	19
SCLC	9	6	15
Others	2	2	4
Healthy controls	55	16	71
Molecular subtypes
EGFR MUTs (+)	46	13	59
KRAS MUTs (+)	2	3	5
No MUTs detected	31	3	34
Not available	36	16	52

Detected subtypes of EGFR MUTs (+) defined as commonly observed point mutations of exon 18 and/or deletions of exon 19 and/or exon 21 insertion mutations and/or point mutation in exon 21 (L858R); KRAS MUTs (+) defined as mutations in codons 12 and/or 13 of exon 2
Ade adenocarcinoma, SCC squamous cell cancer, SCLC small cell lung cancer, EGFR epidermal growth factor receptor, MUTs mutations

ISSN: 1479-5876