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Fig. 4 | Journal of Translational Medicine

Fig. 4

From: HO-1 promotes resistance to an EZH2 inhibitor through the pRB-E2F pathway: correlation with the progression of myelodysplastic syndrome into acute myeloid leukemia

Fig. 4

Characteristics of MDS cells overexpressing EZH2 and HO-1. a The basic information of MDS patients (patient 1, patient 3 and patient 7) is shown in Table 2. These three MDS patients progressed to AML in the later stages. They had experienced both the MDS phase and AML phase. We collected cells from these two phases and cultured them. To ensure the accuracy of the results, we did not culture the cells for long periods. Gene expression was analyzed by high-throughput techniques. The overlapping parts represent the same genes. b The scatterplot shows a correlation among the patients. The Pearson correlation coefficient was used to measure whether two data sets were above a line. It was used to measure the linear relationship between distance variables. A correlation coefficient of 0.8–1.0 represents an extremely strong correlation. c Gene expression differences between three samples and normal donors were compared. The red dots represent the upregulated genes. The green dots represent the downregulated genes. The black dots represent no gene with no difference in genes expression. d Three patients were analyzed by gene chip analysis. Because they all overexpressed EZH2 and HO-1, there were many similarities. D1, D2 and D3 are 3 normal donors. P1 indicates patient 1. P3 indicates patient 3. P7 indicates patient 7. e The genes identified in three samples were analyzed by Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment. All the experiments were repeated, *P < 0.05 (statistical significant)

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