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Table 6 miR expression changes in peripheral blood PFP during the 1st month of chemotherapy

From: Circulating microRNAs as minimal residual disease biomarkers in childhood acute lymphoblastic leukemia

SubgroupsmiRmiR expression changes between sampling dates log2FC (adjusted p)
Day 8–day 0Day 15–day 0Day 33–day 0
Whole cohortmiR-128-3p− 2.86 (3.6*10−7)− 3.15 (3.87*10−7)− 3.60 (7.77*10−10)
miR-181a-5p− 1.33 (3.12*10−2)− 0.93 (NS)− 2.08 (1.01*10−3)
miR-181b-5p− 1.75 (1.48*10−2)− 2.39 (2.05*10−3)− 2.76 (8.78*10−5)
miR-222-3p− 1.25 (1.66*10−2)− 1.03 (NS)− 1.94 (2.09*10−4)
Karyotype: normalamiR-128-3p− 2.49 (2.87*10−3)− 2.29 (3.09*10−2)− 2.99 (4.15*10−4)
miR-181a-5p− 2.58 (2.87*10−3)− 1.79 (NS)− 3.82 (1.16*10−5)
miR-181b-5p− 2.72 (2.87*10−3)− 3.44 (1.51*10−3)− 4.50 (7.63*10−7)
miR-222-3p− 1.23 (NS)− 0.98 (NS)− 2.45 (2.41*10−3)
Karyotype: t(12;21)miR-128-3p− 4.33 (2.20*10−8)− 4.62 (1.74*10−8)− 4.42 (2.12*10−8)
miR-181a-5p− 1.72 (NS)− 0.71 (NS)− 1.13 (NS)
miR-181b-5p− 2.49 (4.11*10−2)− 2.42 (NS)− 2.02 (NS)
miR-222-3p− 2.15 (1.16*10−2)− 1.59 (NS)− 1.82 (3.39*10−2)
Karyotype: hyperdiploidmiR-128-3p− 1.39 (NS)− 2.21 (NS)− 3.31 (NS)
miR-181a-5p− 1.16 (NS)− 0.16 (NS)− 1.01 (NS)
miR-181b-5p0.82 (NS)− 0.98 (NS)− 1.42 (NS)
miR-222-3p0.08 (NS)− 0.20 (NS)− 1.47 (NS)
  1. NS no significant correlation
  2. aNormal karyotype: no alteration on FISH, DNA index diploid and cytogenetics normal or unsuccessful