From: Prognostic nomogram for bladder cancer with brain metastases: a National Cancer Database analysis
Characteristics | Training set (%) | Internal testing set (%) | ||||
---|---|---|---|---|---|---|
Number of cases | High risk | Low risk | Number of cases | High risk | Low risk | |
Age | ||||||
< 65 years | 71 (42) | 32 (18.9) | 39 (23.1) | 22 (33.8) | 11 (16.9) | 11 (16.9) |
≥ 65 years | 98 (58) | 49 (29) | 49 (29) | 43 (66.2) | 21 (32.3) | 22 (33.8) |
Sex | ||||||
Male | 128 (75.7) | 63 (37.3) | 65 (38.5) | 47 (72.3) | 19 (29.2) | 28 (43.1) |
Female | 41 (24.3) | 18 (10.7) | 23 (13.6) | 18 (27.7) | 13 (20) | 5 (7.7) |
Race | ||||||
White | 148 (87.6) | 70 (41.4) | 78 (46.2) | 59 (90.8) | 29 (44.6) | 30 (46.2) |
Black | 16 (9.5) | 8 (4.7) | 8 (4.7) | 4 (6.2) | 3 (4.6) | 1 (1.5) |
Others | 5 (3) | 3 (1.8) | 2 (1.2) | 2 (3.1) | 0 (0) | 2 (3.1) |
Grade | ||||||
Well differentiated | 14 (8.3) | 10 (5.9) | 4 (2.4) | 1 (1.5) | 0 (0) | 1 (1.5) |
Poorly differentiated | 96 (56.8) | 39 (23.1) | 57 (33.7) | 39 (60) | 19 (29.2) | 20 (30.8) |
Unknown | 59 (34.9) | 32 (18.9) | 27 (16) | 25 (38.5) | 13 (20) | 12 (18.5) |
Histology | ||||||
TCC | 94 (55.6) | 49 (29) | 45 (26.6) | 38 (58.5) | 17 (26.2) | 21 (32.3) |
PUC | 42 (24.9) | 15 (8.9) | 27 (16) | 8 (12.3) | 5 (7.7) | 3 (4.6) |
SCC | 10 (5.9) | 3 (1.8) | 7 (4.1) | 7 (10.8) | 2 (3.1) | 5 (7.7) |
Others | 23 (13.6) | 14 (8.3) | 9 (5.3) | 12 (18.5) | 8 (12.3) | 4 (6.2) |
Tumor_Stage | ||||||
Low | 13 (7.7) | 7 (4.1) | 6 (3.6) | 4 (6.2) | 2 (3.1) | 2 (3.1) |
High | 156 (92.3) | 74 (43.8) | 82 (48.5) | 61 (93.8) | 30 (46.2) | 31 (47.7) |
Lymph_nodes | ||||||
No | 87 (51.5) | 39 (23.1) | 48 (28.4) | 33 (50.8) | 16 (24.6) | 17 (26.2) |
Yes | 36 (21.3) | 14 (8.3) | 22 (13) | 17 (26.2) | 9 (13.8) | 8 (12.3) |
Unknown | 46 (27.2) | 28 (16.6) | 18 (10.7) | 15 (23.1) | 7 (10.8) | 8 (12.3) |
Lymph_Vas_Invasion | ||||||
No | 31 (18.3) | 12 (7.1) | 19 (11.2) | 12 (18.5) | 5 (7.7) | 7 (10.8) |
Yes | 29 (17.2) | 13 (7.7) | 16 (9.5) | 6 (9.2) | 3 (4.6) | 3 (4.6) |
Unknown | 109 (64.5) | 56 (33.1) | 53 (31.4) | 47 (72.3) | 24 (36.9) | 23 (35.4) |
Met_Bone | ||||||
No | 112 (66.3) | 47 (27.8) | 65 (38.5) | 44 (67.7) | 26 (40) | 18 (27.7) |
Yes | 57 (33.7) | 34 (20.1) | 23 (13.6) | 21 (32.3) | 6 (9.2) | 15 (23.1) |
Met_Liver | ||||||
No | 129 (76.3) | 61 (36.1) | 68 (40.2) | 50 (76.9) | 25 (38.5) | 25 (38.5) |
Yes | 40 (23.7) | 20 (11.8) | 20 (11.8) | 15 (23.1) | 7 (10.8) | 8 (12.3) |
Met_Lung | ||||||
No | 100 (59.2) | 40 (23.7) | 60 (35.5) | 34 (52.3) | 16 (24.6) | 18 (27.7) |
Yes | 69 (40.8) | 41 (24.3) | 28 (16.6) | 31 (47.7) | 16 (24.6) | 15 (23.1) |
Surgery_Primary | ||||||
Minimal invasive | 65 (38.5) | 27 (16) | 38 (22.5) | 31 (47.7) | 19 (29.2) | 12 (18.5) |
No | 83 (49.1) | 48 (28.4) | 35 (20.7) | 29 (44.6) | 9 (13.8) | 20 (30.8) |
Non-minimal invasive | 21 (12.4) | 6 (3.6) | 15 (8.9) | 5 (7.7) | 4 (6.2) | 1 (1.5) |
Chemotherapy | ||||||
No | 97 (57.4) | 77 (45.6) | 20 (11.8) | 36 (55.4) | 28 (43.1) | 8 (12.3) |
Yes | 72 (42.6) | 4 (2.4) | 68 (40.2) | 29 (44.6) | 4 (6.2) | 25 (38.5) |
Radiation_Therapy | ||||||
No | 89 (52.7) | 50 (29.6) | 39 (23.1) | 38 (58.5) | 14 (21.5) | 24 (36.9) |
Yes | 80 (47.3) | 31 (18.3) | 49 (29) | 27 (41.5) | 18 (27.7) | 9 (13.8) |
Palliative_Care | ||||||
No | 122 (72.2) | 62 (36.7) | 60 (35.5) | 47 (72.3) | 21 (32.3) | 26 (40) |
Yes | 47 (27.8) | 19 (11.2) | 28 (16.6) | 18 (27.7) | 11 (16.9) | 7 (10.8) |
Brain_Confined_Met | ||||||
No | 67 (39.6) | 24 (14.2) | 43 (25.4) | 22 (33.8) | 13 (20) | 9 (13.8) |
Yes | 102 (60.4) | 57 (33.7) | 45 (26.6) | 43 (66.2) | 19 (29.2) | 24 (36.9) |
CDCC_Score | ||||||
0 | 116 (68.6) | 50 (29.6) | 66 (39.1) | 46 (70.8) | 23 (35.4) | 23 (35.4) |
1 | 37 (21.9) | 19 (11.2) | 18 (10.7) | 12 (18.5) | 8 (12.3) | 4 (6.2) |
2 | 10 (5.9) | 7 (4.1) | 3 (1.8) | 5 (7.7) | 1 (1.5) | 4 (6.2) |
3 | 6 (3.6) | 5 (3) | 1 (0.6) | 2 (3.1) | 0 (0) | 2 (3.1) |
Surgery_Met | ||||||
No | 144 (85.2) | 72 (42.6) | 72 (42.6) | 55 (84.6) | 25 (38.5) | 30 (46.2) |
Yes | 25 (14.8) | 9 (5.3) | 16 (9.5) | 10 (15.4) | 7 (10.8) | 3 (4.6) |