Fig. 3

The effect of OLR1 on local tumor carcinogenesis and lung metastases in osteosarcoma cells. a The effect of OLR1 on local tumor carcinogenesis in osteosarcoma cells. Female BALB/c immune-deficient mice were inoculated subcutaneously with stable OLR1-silencing 143b cells and respective controls. The subcutaneous tumors were removed to make frozen specimens; along with the tumor volume and weight were measured. OLR1 silencing suppressed local tumor carcinogenesis of osteosarcoma cells in vivo. b The effect of OLR1 on lung metastases in osteosarcoma cells 143b-shOLR1, and its control cells were cultured and injected through the tail vein into female BALB/c immune-deficient mice. OLR1 knockdown in 143b cells caused reduction in the number of lung metastases