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Table 4 Classical metabolic traits that best predict levels of metabolites differentiating OIS and OIR + T2DM and those associated with disease progression

From: Metabolic signature of obesity-associated insulin resistance and type 2 diabetes

Metabolite Partial correlation (R) Mediator of metabolic disease p value
3-Hydroxylaurate 0.4 ALP 0.003
3-Hydroxyoctanoate 0.4 ALP 0.002
BMI 0.003
3-Hydroxydecanoate 0.83 BMI < 0.001
Glucose 0.4 Insulin < 0.001
TAGs 0.001
1,5-Anhydroglucitol (1,5-AG) − 0.4 Insulin < 0.001
TAGs < 0.001
HOMA-IR 0.004
Ornithine 0.4 ALT < 0.001
Leptin < 0.001
Choline 0.4 ALT < 0.001
Leptin 0.001
Glycerophosphoethanolamine 0.39 BMI < 0.001
  1. A partial correlation analysis by stepwise linear regression was performed using IBM SPSS version 25, R version 3.2.1. A p-value significance level of 0.005 was used