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Table 4 Classical metabolic traits that best predict levels of metabolites differentiating OIS and OIR + T2DM and those associated with disease progression

From: Metabolic signature of obesity-associated insulin resistance and type 2 diabetes

Metabolite

Partial correlation (R)

Mediator of metabolic disease

p value

3-Hydroxylaurate

0.4

ALP

0.003

3-Hydroxyoctanoate

0.4

ALP

0.002

BMI

0.003

3-Hydroxydecanoate

0.83

BMI

< 0.001

Glucose

0.4

Insulin

< 0.001

TAGs

0.001

1,5-Anhydroglucitol (1,5-AG)

− 0.4

Insulin

< 0.001

TAGs

< 0.001

HOMA-IR

0.004

Ornithine

0.4

ALT

< 0.001

Leptin

< 0.001

Choline

0.4

ALT

< 0.001

Leptin

0.001

Glycerophosphoethanolamine

0.39

BMI

< 0.001

  1. A partial correlation analysis by stepwise linear regression was performed using IBM SPSS version 25, R version 3.2.1. A p-value significance level of 0.005 was used