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Table 3 Metabolites that belong to the significantly enriched pathways associated with obesity-associated insulin resistance and T2DM

From: Metabolic signature of obesity-associated insulin resistance and type 2 diabetes

Metabolites Sub pathway Super pathway Beta value Std. error p value
3-Hydroxylaurate Fatty acid monohydroxy Lipid 0.3 0.1 0.002
3-Hydroxyoctanoate Lipid 0.3 0.1 0.008
3-Hydroxydecanoate Lipid 0.3 0.1 0.009
3-Hydroxymyristate Lipid 0.2 0.1 0.012
Glucose Glycolysis gluconeogenesis and pyruvate metabolism Carbohydrate 0.2 0 0.001
15-Anhydroglucitol (1,5-AG) Carbohydrate − 0.4 0.2 0.019
Dimethylarginine (ADMA + SDMA) Urea cycle; arginine and proline metabolism Amino Acid − 0.3 0.1 0.009
Homoarginine Amino Acid − 0.3 0.1 0.017
Ornithine Amino Acid − 0.2 0.1 0.042
2-Oxoarginine* Amino acid − 0.3 0.1 0.045
  1. Linear regression was performed to identify significant metabolites associated with disease progression (lean, OIS, OIR, T2DM) using the R statistical package after correcting for age, gender, BMI and principle components (PC1 and PC2). A p-value significance level of 0.05 was used. Asterisks (*) on IDs of some metabolites indicate that they have not been officially confirmed based on a standard, but their identities are known with confidence [23]