From: Metabolic signature of obesity-associated insulin resistance and type 2 diabetes
Variables | Lean | OIS | OIR | T2DM | p value | All IR (OIR + T2DM) | p value |
---|---|---|---|---|---|---|---|
(N = 32) (all F) | (N = 20) (4M + 16F) | (N = 41) (15M + 26F) | (N = 14) (9M + 5F) | ANOVA | (N = 55) | OIS vs (OIR + T2DM) | |
Age (years) | 28 (6.8) | 35.4 (10.0) | 33.17 (10.1) | 43 (10.9) | < 0.001 | 35.7 (1.49) | 0.92 |
BMI (kg/m2) | 22.7 (2.5) | 45.7 (6.038) | 45.2 (6.8) | 43.3 (7.2) | < 0.001 | 44.8 (0.93) | 0.55 |
SBP (mmHg) | 115.3 (13.7) | 124.9 (15) | 126.9 (19.2) | 132.3 (8.3) | 0.004 | 128 (2.32) | 0.42 |
DBP (mmHg) | 70.7 (7.8) | 74.2 (23.257) | 74.0 (11.8) | 77.1 (8.8) | 0.52 | 74.8 (1.51) | 0.88 |
MAP (mmHg) | 85.6 (8.7) | 85.2 (12.82) | 91.7 (12.8) | 95.8 (8.21) | 0.01 | 92.7 (1.61) | 0.03 |
Cholesterol (mmol/l) | 4.3 (0.97) | 4.5 (1.24) | 4.8 (1.2) | 4.9 (0.70) | 0.27 | 4.8 (0.14) | 0.24 |
LDL-cholesterol (mmol/l) | 2.5 (0.96) | 2.9 (0.89) | 3.0 (1.05) | 2.8 (0.66) | 0.32 | 3.0 (0.13) | 0.74 |
HDL-cholesterol (mmol/l) | 1.4 (0.35) | 1.2 (0.36) | 1.4 (0.59) | 1.2 (0.2) | 0.18 | 1.4 (0.07) | 0.12 |
Triacylglycerol (mmol/l) | 0.8 (0.28) | 1.1 (0.39) | 1.3 (0.62) | 1.8 (0.8) | < 0.001 | 1.4 (0.09) | 0.04 |
Triglyceride/HDL | 0.7 (0.56) | 1.0 (0.45) | 1.1 (0.77) | 1.6 (1.1) | 0.01 | 1.2 (0.12) | 0.28 |
Leptin (ng/ml) | NA | 60.2 (29.9) | 51.2 (21.8) | 38.9 (23.8) | 0.05* | 48.0 (3.09) | 0.06 |
Adiponectin (ÎĽg/ml) | NA | 4.2 (3.19) | 3.1 (1.41) | 3.4 (1.7) | 0.5* | 3.1 (0.30) | 0.25 |
IL6 (pg/ml) | NA | 3.7 (2.07) | 4.3 (2.1) | 4.0 (2.0) | 0.45* | 4.2 (0.27) | 0.26 |
Insulin (pmol/l) | NA | 5.3 (1.04) | 6.3 (2.7) | 11.3 (5.6) | < 0.001* | 7.6 (0.57) | 0.02 |
FBG (mmol/l) | 5.0 (0.39) | 6.3 (2.30) | 17.9 (8.8) | 15.1 (8.6) | < 0.001 | 17.2 (1.18) | < 0.001 |
HOMA-IR | NA | 1.5 (0.55) | 5.22 (3.2) | 6.4 (3.0) | < 0.001* | 5.5 (0.43) | < 0.001 |
TP (g/l) | 73.7 (3.40) | 70.3 (4.36) | 71 (4.4) | 74.3 (7.2) | 0.04 | 71.8 (0.89) | 0.34 |
ALP (U/l) | 60.3 (17.1) | 70.2 (18.38) | 72.5 (16.1) | 95.5 (38.1) | < 0.001 | 77.9 (3.46) | 0.21 |
ALT (U/l) | 12.6 (5.5) | 22.9 (15.16) | 31.3 (25.6) | 30.9 (19.0) | 0.002 | 31.2 (3.33) | 0.15 |
AST (U/l) | 15.5 (4.7) | 20.8 (7.84) | 24.9 (16.7) | 21.7 (10.7) | 0.04 | 24.1 (2.17) | 0.36 |
Bilirubin (ÎĽmol/l) | 21.2 (4.6) | 8.30 (3.84) | 8.2 (4.4) | 8.5 (3.5) | 0.55 | 8.0 (0.60) | 0.9 |