Fig. 8

TRPV1 inhibition reduces pain sensitivities in wild-type (WT) and B1 and B2 receptor knockout (B1KO, B2KO) mice. WT, B1KO and B2KO mice were subjected to tibial fracture and received a single injection of SB 366791 (1 mg/kg) at time 0. Behaviors were recorded during 8 h and the subsequent day. Each bar represents mean ± SEM of 6 mice per group. Data were subjected to Friedman’s test followed by Wilcoxon signed rank test. *P < 0.05 compared with fractured untreated, i.e. WT, B1KO and B2KO + saline or + DMSO respectively