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Fig. 7 | Journal of Translational Medicine

Fig. 7

From: Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists

Fig. 7

COX inhibition with ketoprofen (K) reduces pain sensitivities in wild-type (WT) mice but has no effect in B1 and B2 receptor knockout (B1KO, B2KO) mice. WT, B1KO and B2KO were subjected to tibial fracture and received a single injection of K (50 mg/kg body weight) at time 0. Behaviors were recorded during 4 h. Each bar represents mean ± SEM of 6 mice per group. Data were subjected to Friedman’s test followed by Wilcoxon signed rank test. *P < 0.05 compared with fractured untreated WT

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