Fig. 6

B1 and B2 receptor antagonists reduce mechanical (a), thermal (b) sensitivities and subjective pain (c) on the fractured tibia side in wild-type (WT) mice. Experiments were conducted as described in Fig. 1. At time 0, the B2 receptor antagonist Icatibant (HOE 140) was given as a single subcutaneous injection (250 µg/kg). B1 receptor antagonists were given either as gavage using SSR240612 (10 mg/kg body weight) or as a single subcutaneous injection of R954 (10 mg/kg body weight). Behaviors were recorded for 8 h and then once the subsequent day 24 h after drug administration. Each bar represents mean ± SEM of 6 mice per group. B: baseline. Data were subjected to Friedman’s test followed by Wilcoxon’ signed rank test. *, ^# and ^€P < 0.05 compared with saline-treated WT mice