|
Harvest time post-exposure
|
Exposure type
|
Number of rats with organs and blood storeda
|
|---|
|
Day 1
|
Naïve
|
6
|
|
ISO control
|
5
|
|
26.5–35.5b mg dust/m3
|
6
|
|
Day 30
|
Naïve
|
6
|
|
ISO control
|
6
|
|
26.6–32.0 mg dust/m3
|
6
|
|
Day 60
|
Naïve
|
6
|
|
ISO control
|
6
|
|
32.7–35.5 mg dust/m3
|
6
|
|
Day 120
|
Naïve
|
6
|
|
ISO control
|
6
|
|
32.7–35.5 mg dust/m3
|
6
|
|
Day 240
|
Naïve
|
12
|
|
ISO control
|
6
|
|
32.0–35.5 mg dust/m3
|
5
|
|
Day 360
|
Naïve
|
6
|
|
ISO control
|
6
|
|
26.6–42.8 mg dust/m3
|
17
|
|
Total
| |
123
|
- Tissues from the male F344 rats of the earlier intratracheal inhalation WTC dust-exposure studies (also 2 h/day on 2 consecutive days) are also available in the Biobank, although the group sizes are not presented here
- a All rats were males. Organs isolated for each rat included the heart, aortic arches, prostate, kidney, liver, thyroid, spleen; these materials were frozen and/or stored in formalin. TA leg muscle, plasma, serum, bone marrow and lung lavage fluid (supernatant) were only frozen. Some lungs were lavaged and then frozen; others were inflated and then fixed
- b Values shown cover range of dust levels presented to the rats over the course of their respective two exposures. Target value each day was ≈ 33–35 mg/m3. To avoid bias, rats from any given exposure set were randomly allocated into the various post-exposure time groups; this explains commonality among ranges indicated
