Complementary biobank of rodent tissue samples to study the effect of World Trade Center exposure on cancer development

Table 1 Inventory of NYU bio-samples from WTC dust-exposed/control SHR rats

Harvest time post-exposure	Exposure type	Number of rats with organs and blood stored^a
Day 1	Naïve	6
	ISO control	5
	26.5–35.5^b mg dust/m³	6
Day 30	Naïve	6
	ISO control	6
	26.6–32.0 mg dust/m³	6
Day 60	Naïve	6
	ISO control	6
	32.7–35.5 mg dust/m³	6
Day 120	Naïve	6
	ISO control	6
	32.7–35.5 mg dust/m³	6
Day 240	Naïve	12
	ISO control	6
	32.0–35.5 mg dust/m³	5
Day 360	Naïve	6
	ISO control	6
	26.6–42.8 mg dust/m³	17
Total		123

Tissues from the male F344 rats of the earlier intratracheal inhalation WTC dust-exposure studies (also 2 h/day on 2 consecutive days) are also available in the Biobank, although the group sizes are not presented here
^a All rats were males. Organs isolated for each rat included the heart, aortic arches, prostate, kidney, liver, thyroid, spleen; these materials were frozen and/or stored in formalin. TA leg muscle, plasma, serum, bone marrow and lung lavage fluid (supernatant) were only frozen. Some lungs were lavaged and then frozen; others were inflated and then fixed
^b Values shown cover range of dust levels presented to the rats over the course of their respective two exposures. Target value each day was ≈ 33–35 mg/m³. To avoid bias, rats from any given exposure set were randomly allocated into the various post-exposure time groups; this explains commonality among ranges indicated

ISSN: 1479-5876