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Table 6 MiRNA expression in breast cancer and benign breast tissue, measured by PCR

From: Differential expression of the miR-17-92 cluster and miR-17 family in breast cancer according to tumor type; results from the Norwegian Women and Cancer (NOWAC) study

miRNA Breast cancer Benign tissue logFC p*
Mean ± SD Mean ± SD
let-7b-5p 3.41 ± 1.11 4.28 ± 1.05 − 0.87 0.0094
let-7c 2.54 ± 0.99 3.84 ± 0.90 − 1.30 4.76E−5
miR-126-3p 2.98 ± 1.04 4.24 ± 0.79 − 1.26 5.42E−5
miR-126-5p − 2.05 ± 1.00 − 0.86 ± 0.80 − 1.18 6.19E−5
miR-143-3p 2.84 ± 1.16 4.18 ± 0.81 − 1.35 6.19E−5
miR-145-5p 3.31 ± 1.53 5.98 ± 0.69 − 2.67 1.79E−8
miR-155-5p − 0.54 ± 1.37 − 2.23 ± 1.11 1.69 5.04E−5
miR-146a-5p − 0.48 ± 1.36 − 1.22 ± 1.08 0.74 0.048
miR-3182 − 7.24 ± 1.71 − 9.17 ± 1.43 1.93 0.028
miR-17-5p − 4.70 ± 1.45 − 4.92 ± 1.11 0.22 0.60
miR-20a-5p 2.36 ± 1.18 2.29 ± 0.67 0.069 0.81
miR-92a-3p 1.96 ± 1.03 2.60 ± 0.76 − 0.65 0.025
miR-106b-5p 0.45 ± 1.03 − 0.84 ± 0.61 1.29 3.81E−5
miR-93-5p 1.76 ± 1.03 0.75 ± 0.56 1.01 0.00031
  1. Expression levels are presented as mean (standard deviation) of normalized PCR quantification cycle (Cq) values based on the average of the normalizer assay detected in all samples and the formula: normalized Cq = average Cq (all samples) − assay Cq (sample). Negative PCR expression values indicate lower expression levels compared to the normalizer
  2. * False discovery rate (FDR) adjusted p-value. E indicates exponential number