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Table 4 Expression of miRNAs in the miR-17-92 and miR-106b-25 clusters according to histologic grade

From: Differential expression of the miR-17-92 cluster and miR-17 family in breast cancer according to tumor type; results from the Norwegian Women and Cancer (NOWAC) study

MiRNA Tissue Grade n Mean (SD) Contrasts p*
miR-17-5p Benign 36 6.67 (0.68)   
Cancer All 102 6.32 (0.66) Cancer vs benign 0.014
Cancer 1 32 6.10 (0.45) Grade 1 vs 2 and 3 0.0040
Cancer 2 41 6.16 (0.48) Grade 1 and 2 vs 3 2.45E−5
Cancer 3 27 6.82 (0.85) Grade 1 vs 3 6.84E−5
miR-20a-5p Benign 36 7.34 (0.74)   
Cancer All 102 6.69 (0.60) Cancer vs benign 1.23E−6
Cancer 1 32 6.54 (0.38) Grade 1 vs 2 and 3 0.014
Cancer 2 41 6.52 (0.39) Grade 1 and 2 vs 3 2.45E−5
Cancer 3 27 7.14 (0.82) Grade 1 vs 3 8.50E−5
miR-92a-3p Benign 36 7.79 (0.62)   
Cancer All 102 7.23 (0.52) Cancer vs benign 1.23E−6
Cancer 1 32 7.19 (0.47) Grade 1 vs 2 and 3 0.27
Cancer 2 41 7.06 (0.42) Grade 1 and 2 vs 3 0.00037
Cancer 3 27 7.55 (0.59) Grade 1 vs 3 0.0068
miR-106b-5p Benign 36 6.68 (0.59)   
Cancer All 102 6.56 (0.51) Cancer vs benign 0.24
Cancer 1 32 6.36 (0.38) Grade 1 vs 2 and 3 0.0019
Cancer 2 41 6.49 (0.44) Grade 1 and 2 vs 3 6.84E−5
Cancer 3 27 6.91 (0.61) Grade 1 vs 3 6.84E−5
miR-93-5p Benign 36 6.81 (0.41)   
Cancer All 102 7.00 (0.56) Cancer vs benign 0.095
Cancer 1 32 6.80 (0.39) Grade 1 vs 2 and 3 0.0032
Cancer 2 41 6.92 (0.47) Grade 1 and 2 vs 3 6.84E−5
Cancer 3 27 7.39 (0.69) Grade 1 vs 3 8.50E−5
miR-25-3p Benign 36 6.63 (0.33)   
Cancer All 102 6.54 (0.33) Cancer vs benign 0.19
Cancer 1 32 6.44 (0.23) Grade 1 vs 2 and 3 0.013
Cancer 2 41 6.48 (0.28) Grade 1 and 2 vs 3 0.00016
Cancer 3 27 6.75 (0.41) Grade 1 vs 3 0.00043
  1. Expression levels are given as the mean (standard deviation) of log2 transformed intensity values (Hy3) by microarray analyses
  2. * False discovery rate (FDR) adjusted p-value. E indicates exponential number