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Table 3 Characteristics of patients with acute cervical spinal cord injury stratified by outcome (excellent/non-excellent)

From: Serial plasma DNA levels as predictors of outcome in patients with acute traumatic cervical spinal cord injury

 

Excellent outcome (N = 21)

Non-excellent outcome (N = 23)

p value

Odds ratio

95% CI (lower, upper)

Age (year), median (IQR)

45 (36.5, 56)

53 (31, 63)

.102

  

Male

17

19

1.000

1.059

0.488, 2.297

Body mass index

25.2 (21.1, 28.3)

24.3 (20.9, 26.9)

.860

  

Level of SCI

  

1.000

.929

0.494, 1.746

 C1–C4

13

15

   

 Below C4

8

8

   

Injury Severity Score at admission

 Total, median (IQR)

16 (13, 21)

21 (16, 43)

.022

  

 AIS-head/neck, median (IQR)

4 (3, 4)

4 (4, 5)

.040

  

 AIS-thorax, median (IQR)

0 (0, 0)

0 (0, 1)

.055

  

 AIS-abdomen, median (IQR)

0 (0, 0)

0 (0, 0)

.591

  

 AIS-extremities, median (IQR)

0 (0, 2)

0 (0, 1)

.608

  

JOA score at admission, median (IQR)

6 (4.5, 12)

4 (2, 4)

≤ .001

  

Neurosurgical intervention

 Emergent surgery

6

17

.006

2.738

1.307, 5.734

 Elective surgery

12

16

.533

1.313

0.715, 2.411

Laboratory data at presentation, Median (IQR)

 WBC (× 103/ml)

12.9 (9.3, 16.0)

10.0 (6.3, 14.3)

.105

  

 Platelet counts (× 103/ml)

225 (181, 262)

211 (179, 260)

.724

  

 Creatinine

0.91 (0.73, 1.0)

0.94 (0.66, 1.05)

.787

  

 AST

27 (24, 36)

31 (28, 38.3)

.202

  

 ALT

26 (18, 32)

27 (15, 37)

.814

  

 Sugar

133 (108, 153)

121 (97, 135)

.231

  

Plasma nuclear DNA (ng/ml) at presentation, Median (IQR)

 Day 1

26.9 (17.8, 74.2)

58.1 (32.6, 160)

.018

  

 Day 14

40.5 (24.4, 51.1)

61.8 (45.9, 139)

.001

  

 Day 30

20.0 (15.4, 30.9)

33.1 (23.8, 49.7)

.014

  

 Day 90

15.2 (11.9, 28.2)

21.0 (9.6, 37.1)

.586

  

 Day 180

18.3 (12.5, 28.2)

20.0 (17.2, 32.6)

.344

  

Plasma mitochondrial DNA (ng/ml) at presentation, Median (IQR)

 Day 1

25.9 (14.6, 99.3)

46.1 (26.9, 202.5)

.264

  

 Day 14

51.0 (23.0, 133)

76.9 (50.7, 168)

.297

  

 Day 30

33.6 (18.2, 83.9)

48.6 (22.4, 90.7)

.425

  

 Day 90

18.9 (10.7, 29.6)

34.4 (15.1, 65.9)

.220

  

 Day 180

27.0 (18.9, 51.8)

50.2 (12.5, 68.8)

.501

  

Days of ICU stay

3 (2, 6)

5.5 (3, 16.8)

.026

  

Days of neurosurgical stay

12 (4.5, 16.5)

17 (8, 30)

.036

  
  1. Data are presented either as absolute numbers or as medians with the interquartile range. Statistical significance was set at a level of p = 0.05. Statistical variance between groups was assessed by the Fisher’s exact test for discrete variables and by the Mann–Whitney U test for continuous variables
  2. CI confidence interval, IQR interquartile range, AIS Abbreviated Injury Scale, JOA Japanese Orthopaedic Association, WBC white blood cell, AST aspartate aminotransferase, ALT alanine aminotransferase, DNA deoxyribonucleic acid