Table 3 Investigation of cases with discordant 90-gene expression signature results
From: 90-gene signature assay for tissue origin diagnosis of brain metastases
Case | Age | Gender | Resection | Grade | Immunohistochemistry | Reference diagnosis | Histology | Type prediction |
|---|---|---|---|---|---|---|---|---|
1 | 53 | Male | Cerebellum | Poorly differentiated | TTF-1(−), CK7(+), CK5/6(+), P63(+) | Lung | SCC | Neuroendocrine |
2 | 75 | Male | Cerebellum | Poorly differentiated | TTF-1(−), CK7(+), CK5/6(+), P63(−), CGA(−), CK(pan)(+), Ki-67(+), Syn(−) | Lung | SCC | Germ cell |
3 | 57 | Male | Cerebellum | Poorly differentiated | TTF-1(−), CK7(+), CK5/6(+), P63(+), CGA(−), CK(+), Syn(−), Napsin A(−), CDX2(−), CK20(−) | Lung | SCC | Urinary |
4 | 62 | Male | Cerebellum | Poorly differentiated | TTF-1(−), CK5/6(+), P63(−), GFAP(−), CK(pan)(+), Henatocyte(focal+), EBER(−), CDX2(−), | Lung | AC | Urinary |
5 | 52 | Male | Occipital lobe | Poorly differentiated | TTF-1(−), CK7(+), CK5/6(+), P63(+), GFAP(−), Vimentin(+), PR(−), EMA(focal+) | Lung | SCC | Urinary |