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Table 3 Investigation of cases with discordant 90-gene expression signature results

From: 90-gene signature assay for tissue origin diagnosis of brain metastases

Case Age Gender Resection Grade Immunohistochemistry Reference diagnosis Histology Type prediction
1 53 Male Cerebellum Poorly differentiated TTF-1(−), CK7(+), CK5/6(+), P63(+) Lung SCC Neuroendocrine
2 75 Male Cerebellum Poorly differentiated TTF-1(−), CK7(+), CK5/6(+), P63(−), CGA(−), CK(pan)(+), Ki-67(+), Syn(−) Lung SCC Germ cell
3 57 Male Cerebellum Poorly differentiated TTF-1(−), CK7(+), CK5/6(+), P63(+), CGA(−), CK(+), Syn(−), Napsin A(−), CDX2(−), CK20(−) Lung SCC Urinary
4 62 Male Cerebellum Poorly differentiated TTF-1(−), CK5/6(+), P63(−), GFAP(−), CK(pan)(+), Henatocyte(focal+), EBER(−), CDX2(−), Lung AC Urinary
5 52 Male Occipital lobe Poorly differentiated TTF-1(−), CK7(+), CK5/6(+), P63(+), GFAP(−), Vimentin(+), PR(−), EMA(focal+) Lung SCC Urinary
  1. SCC squamous cell carcinomas, AC adenocarcinomas