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Table 1 Model parameters

From: Predicting response to pembrolizumab in metastatic melanoma by a new personalization algorithm

Model parameter Definition Estimated value Units Source
\(\alpha_{im}\) Activation rate of APCs 1.161 × 103 to 2.986 × 103 Cells/day [27, 28]
\(b\) Number of tumor cells, required for reaching half of the maximal APC activation rate 3.704 × 104 to 1.476 × 105 Cells [27,28,29]
\(\mu_{APC}\) Death rate of APCs 0.2310 Day−1 [30, 31]
\(a_{pem}\) Maximum effect of pembrolizumab on activation of CD8+ T cells \(1 \times 10\) to \(1 \times 10^{4}\) Model simulations
\(\alpha_{eff}\) Activation rate of naïve antigen-specific CD8+ T cells 0.8318 Day−1 [32]
\(b_{pem}\) Maximum effect of pembrolizumab on the exhaustion rate of CD8+ T cells 0.9 Model simulations
\(\mu_{eff}\) Death rate of Effector CD8+ T cells 0.1777 Day−1 [33]
\(\gamma_{mel}\) Net growth rate of tumor cells 0.003269 to 0.08664 Day−1 [34]
\(\upsilon_{mel}\) Innate death rate of tumor cells by effector CD8+ T cells 0.1245 Day−1 [35,36,37]
\(g\) Number of tumor cells, at which the elimination rate reaches half of its maximal value 2.019 × 107 to 1 × 108 Cells [36, 38]