Table 1 Model parameters
From: Predicting response to pembrolizumab in metastatic melanoma by a new personalization algorithm
Model parameter | Definition | Estimated value | Units | Source |
|---|---|---|---|---|
\(\alpha_{im}\) | Activation rate of APCs | 1.161 × 103 to 2.986 × 103 | Cells/day | |
\(b\) | Number of tumor cells, required for reaching half of the maximal APC activation rate | 3.704 × 104 to 1.476 × 105 | Cells | |
\(\mu_{APC}\) | Death rate of APCs | 0.2310 | Day−1 | |
\(a_{pem}\) | Maximum effect of pembrolizumab on activation of CD8+ T cells | \(1 \times 10\) to \(1 \times 10^{4}\) | – | Model simulations |
\(\alpha_{eff}\) | Activation rate of naïve antigen-specific CD8+ T cells | 0.8318 | Day−1 | [32] |
\(b_{pem}\) | Maximum effect of pembrolizumab on the exhaustion rate of CD8+ T cells | 0.9 | – | Model simulations |
\(\mu_{eff}\) | Death rate of Effector CD8+ T cells | 0.1777 | Day−1 | [33] |
\(\gamma_{mel}\) | Net growth rate of tumor cells | 0.003269 to 0.08664 | Day−1 | [34] |
\(\upsilon_{mel}\) | Innate death rate of tumor cells by effector CD8+ T cells | 0.1245 | Day−1 | |
\(g\) | Number of tumor cells, at which the elimination rate reaches half of its maximal value | 2.019 × 107 to 1 × 108 | Cells |